Investigation of the Inhibitory Effect of Platycodin D in Human Transitional Cell Carcinoma Cell Line 5637

Platycodin D is an active component isolated from Chinese herb Platycodonis radix with various pharmacological activities, such as antitussive, expectorant, anti-inflammatory, and analgesic effects. Interestingly, platycodin also exerts anticancer effects against several types of cancer. However, few studies on the anti-tumour urinary bladder cancer have been reported. In this study, we explored effect human its mechanisms in vitro vivo . We found that had significant anti-proliferative four cells, especially 5637 cell line, exerted these by preventing cycle progression G 0 /G 1 to S phase, down-regulating Ki-67 cyclin D1 protein expression up-regulating P21 expression. Furthermore, inhibited migration decreasing twist-related (Twist1) matrix metallopeptidase 2 (MMP2) tumour-suppressive tumour-bearing nude mice. increased caspase-9, caspase-8, caspase-3, p53 decreased Bcl-2 tumour tissues. Taken together, our results provide a theoretical basis for application treating